Front Immunol. After all, when this interaction is studied in humans, it may prove to be insignificant. Her work is regularly featured in media such as First For Women, Woman's World, and Natural Health. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Keep all medications and herbal products away from children and pets. Consult your doctor before using this product. Before using this product, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: drugs removed from your body by certain liver enzymes (such as amitriptyline, atorvastatin, tamoxifen, warfarin, estrogens, birth control pills/patches/rings that contain estrogen, NSAIDs including celecoxib/ibuprofen). Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). Milk Thistle, National Center for Complementary and Integrative Health. Milk thistle is a plant whose fruit and seeds have been used for more than 2,000 years as a treatment for liver and bile duct disorders. Brittany Lubeck, RD, is a nutrition writer and registered dietitian with a master's degree in clinical nutrition. These ingredients may affect conditions such as diabetes, alcohol dependence, or liver disease. Should I avoid certain foods while taking Milk Thistle Capsule? 2016;5147468. doi:10.1155/2016/5147468. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. Some, but not all, milk thistle supplements are vegan. J Diabetes Res. de Avelar CR, Pereira EM, de Farias Costa PR, et al. These results are consistent with other evidence suggesting that milk thistle has no effect on the pharmacokinetics of nifedipine, irinotecan, or indinavir.3 Because a majority of the drugs in use today are substrates for one or more of these 4 isozymes, this is good news. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Agency for Healthcare Research and Quality (US); 2000. Occasionally, people report various digestive side effects. Milk thistle is native to Europe and was introduced into North America by early colonists. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. An important part of taking supplements is proper storage. Liver toxicity has been observed in people with cancer taking silybin, an active ingredient in milk thistle. Spiny stems branch at the top and reach heights of 5 to 10 feet. Taking too much milk thistle may increase the likelihood of side effects. Enter other medications to view a detailed report. Milk Thistle; Silybum marianum; St. Mary's Thistle. Vegetable Oil: Nutrition Fac Olive Oil Vs. Some of the studies have been of poor quality, too. Check if they have been certified organic following U.S. Department of Agriculture (USDA) regulations. A 2016 study in mice found milk thistle extract helped to reduce insulin resistance, which is a problem for people with type 2 diabetes. What Happens If I Take Too Much Milk Thistle? Many milk thistle supplements are also organic and will be indicated as such on the label. Dosage is also typically listed on the nutrition label of supplements. However, if you develop an allergic reaction after taking milk thistle, stop use and consult your doctor. Website: https://pubmed.ncbi.nlm.nih.gov/. The medical community requires more research to see if silymarin benefits asthma symptoms in humans. It is unknown if this product passes into breast milk. Silybum (milk thistle) is a genus of two species of thistles in the family Asteraceae. Milk thistle (silymarin) is a flowering herb related to the daisy and ragweed family. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. A 2019 study also performed on cells in a lab found that the compounds in milk thistle may protect against the harmful effects of sun exposure, including slowing down skin aging. Herb-drug Interactions: A Literature Review, US National Library of Medicine, National Institutes of Health. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. By Brittany Lubeck, RD Milk thistle (Silybum marianum) is a herb loaded with antioxidants and is known for its anti-inflammatory properties. However, the evidence is conflicting. One of milk thistle's traditional uses is easing indigestion. Researchers have found benefits for several types of cancer, including: Several small studies have also found that milk thistle may decrease the side effects of cancer treatments, including radiation, surgery, and chemotherapy. Asthma is a chronic inflammatory disease where the immune system overreacts to environmental triggers, leading to inflammation in the airways. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Rev Diabet Stud. The effects of milk thistle (Silybum marianum) on human cytochrome P450 activity. Studies of milk thistle coadministered with various drugs in humans suggest it is unlikely to affect the most common cytochrome, the P450 (CYP450) isozyme. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Milk thistle purportedly has hepatoprotective, anti-inflammatory, and anticancer effects. Enter other medications to view a detailed report. Merlin Annie Raj, RD (Registered Dietitian), Merlin Annie Raj is a Registered Dietitian based out of Hyderabad, India. She has 14 years of experience in Clinical Nutrition as well as teaching Nutrition and Dietetics to undergraduate and postgraduate students. ODS seeks to strengthen knowledge and understanding of dietary supplements by evaluating scientific information, supporting research, sharing research results, and educating the public. Milk thistle can also cause an allergic reaction in some people. Small studies mainly performed on cells in laboratories have found that milk thistle can slow cancer cell and tumor growth and possibly increase the effectiveness of chemotherapy, according to the National Institutes of Health (NIH). Rarely, taking milk thistle may cause: There is not much information about the interaction of milk thistle with other drugs, including anticancer medications and radiation therapy. Its seed might protect liver cells from toxic chemicals and drugs. However, consult your doctor for the best advice. He graduated from SRM University, Chennai, and has a Professional Certificate in Food, Nutrition & Research from Wageningen University. But the herb is also believed to be beneficial for other health issues. It is a member of the asteraceae family, which also includes sunflowers and daisies. Milk thistle is promoted as a dietary supplement for hepatitis, cirrhosis, jaundice, diabetes, indigestion, and other conditions. Potensi Tinggi Setiap kapsul mengandung 1.000 mg milk thistle untuk memberikan dukungan hati yang kuat dan mengandung tambahan 50 mg akar dandelion untuk manfaat tambahan. Effect of silymarin on chemical, functional, and morphological alterations of the liver. Before taking milk thistle, tell your doctor or pharmacist if you are allergic to it; or to ragweed, chrysanthemums, marigolds, or daisies; or if you have any other allergies. Read our. Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). Therefore, it is important to talk to your healthcare provider about any supplements you plan to take and to check in about any potential interactions with other supplements or medications. Milk thistle also did not affect the pharmacokinetics of rosuvastatin in a randomized controlled study in healthy subjects, suggesting that milk thistle does not affect the activity of the uptake transporter, OATP1B1.5. Copyright 2011 - 2023 IncNut Stylecraze Private Limited. Include all brand names and combination drug names. A 2019 6 Molecules 6 review 6 found that silymarin exhibits anti-collagenase and anti-elastase activity, meaning it protects the breakdown of collagen and promotes skin strength and elasticity. Researchers also found in another study that milk thistle had antioxidant and anti-aging effects on human skin cells in a laboratory environment. Consult your doctor before breast-feeding. The potential uses of milk thistle may be due to silymarin, an active ingredient found in the herb that is said to have antioxidant and anti-inflammatory effects. We avoid using tertiary references. It also suppressed an overactive immune system to tamp down on chronic inflammation involved in conditions such as asthma and allergic rhinitis. Our team thoroughly researches and evaluates the recommendations we make on our site. We encourage you to discuss any decisions about treatment or care with your health care provider. Take charge of your healthtalk with your health care providers about any complementary health approaches you use. Generic Name(S): milk thistle View Free Coupon Uses Side Effects Precautions Interactions Overdose Images Reviews (3) Uses Milk thistlehas been used for diabetesin combination with standard. Articles on StyleCraze are backed by verified information from peer-reviewed and academic research papers, reputed organizations, research institutions, and medical associations to ensure accuracy and relevance. But are there any proven health benefits of it? MNT is the registered trade mark of Healthline Media. Effects of Silybum marianum (L.) Gaertn. In animal studies, the antioxidant and radical-scavenging properties of silibinin in milk thistle were found to reduce tumors (16). Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Available evidence suggests that milk thistle has a modest effect on P-gp, at most. 2016;2016:5147468. doi:10.1155/2016/5147468. You can find milk thistle as loose-leaf tea or in tea bags. Milk thistle is native to Europe and was introduced into North America by early colonists. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Rambaldi, A.; Jacobs, B.; Iaquinto G, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic Cochrane hepato-biliary group review with meta-analyses of randomized clinical trials. Milk thistle: early seeds of potential, The Lancet Oncology, US National Library of Medicine, National Institutes of Health. Consult your healthcare provider if this applies to you. A service of the National Library of Medicine, PubMed contains publication information and (in most cases) brief summaries of articles from scientific and medical journals. Take your next dose at the regular time. Phytomedicine. Common Names:milk thistle, Mary thistle, holy thistle, Latin Names:Silybum marianum, synonym Carduus marianus. Does Milk Thistle Capsule interact with other medications? Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study. Milk thistle is sold as an oral capsule, tablet and liquid extract. Cymbalta side effects (more detail) Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Natural Medicines website. Regardless, interactions are still possible. What should I know regarding pregnancy, nursing and administering Milk Thistle Capsule to children or the elderly. Horn and Hansten are both professors of pharmacy at the University of Washington School of Pharmacy. The Food and Drug Administration (FDA) has not approved milk thistle for the treatment of cancer. Small Business Research Grant Program (SBIR), About Research Training and Career Development, Training Grant Application, Review, and Award Process, Integrative Medicine Research Lecture Series, Division of Extramural Research Sponsored by NCCIH, Division of Intramural Research Conducted at NCCIH, Know the Science: How Medications and Supplements Can Interact, Know the Science: 9 Questions To Help You Make Sense of Health Research, How To Find Information About Complementary Health Approaches on PubMed, Dietary Supplements: What You Need To Know. Steep milk thistle tea bags or loose-leaf milk thistle tea in hot water. Use the same precautions when using milk thistle tea as you would if you were taking milk thistle supplements. The following list is not exhaustive. Milk thistle ( Silybum marianum L. He has written over 300 articles about ingredients and their benefits for the skin, hair, and health. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. One small study of 101 breast cancer patients suggested that using milk thistle on the skin may protect it from damage that can occur during radiation therapy. 2018;9:1903. doi:10.3389/fimmu.2018.01903. Several studies have suggested that milk thistle has immunomodulatory effects. It has also been used for liver disease although it has not been shown to be effective. (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial, Silymarin in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials, Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials, The Natural agonist of estrogen receptor silibinin plays an immunosuppressive role representing a potential therapeutic tool in rheumatoid arthritis, Silybin and the liver: from basic research to clinical practice, Safety and toxicity of silymarin, the major constituent of milk thistle extract: An updated review, The therapeutic potential of milk thistle in diabetes, Effect of curcumin supplementation on disease severity in patients with liver cirrhosis: a randomized controlled trial, Effects of vitamin E on chronic hepatitis C genotype 3: a randomized, double-blind, placebo-controlled study, Resveratrol for the management of diabetes and its downstream pathologies, Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects: summary. Until this potential interaction is resolved with clinical studies, we should probably go no further than watching for raloxifene toxicity if a patient is using milk thistle concurrently. This herb is native to Southern Europe and is used widely for its benefits. Doctors mainly use the plant to treat liver problems, but some people claim it can lower cholesterol and help manage type 2 diabetes. The following conditions are contraindicated with this drug. gallbladder disorders. If you are currently being treated with any of the following medications, you should not use milk thistle without first talking to your healthcare provider. Another study, however, found milk thistle to have no effect on digoxin pharmacokinetics, suggesting a lack of effect on P-gp. The active ingredient in milk thistle is called silymarin. Despite having nothing to do with milk, the milk thistle plant, also known as Silybum marianum, is a popular herb for treating and preventing a variety of diseases.. Milk thistle is available as a supplement from many health food stores. Milk thistle might also decrease hormone levels in the body (5). Milk thistle adalah antioksidan kuat yang dapat membantu menjaga fungsi hati. In:Drugs and Lactation Database (LactMed). The medical community needs more evidence to prove that milk thistle benefits human livers in the same way. Milk thistle may interfere with the following medications, because both milk thistle and these medications are broken down by the same liver enzymes: Allergy drugs -- such as fexofenadine (Allegra) Drugs for high cholesterol -- such as lovastatin (Mevacor, Altocor) Milk thistle grows in Europe but can also be found in the United States and South America. Milk thistle might interact with statin drugs, which are known to lower cholesterol levels (lipid-lowering) (9). And consult your doctor for the treatment of cancer effects will subside once you stop using milk benefits. 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