It is the flea and tick component that is the problem. He has never acted like he was in pain. Thannks !! Advised I could call Simparica for reimbursement or to report side effects. He has been very healthy, and it does not seem to bother him, but it is becoming more noticeable recently. That is the only thing that has changed in her routine. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. She had right sided weakness, with right sided neglect( the inability to process stimuli with impaired spatial recognition ). He has been getting groomed since he was 3 months old but we've noticed that he has been getting more anxious with time. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. My dog has had a previous back leg surgery. Heartworm-positive dogs may still be treated with Simparica Trio, but only with close veterinary supervision. All they care about is the money and not the animal. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. Hoping you are the lucky ones!! Banfield Hospital pushed" Simparica Trio" on our 16 year old Toy Poodle which caused a neurological disorder of sundowner to the point of him having two days straight of constant seizures, repetitive pacing and extreme agitation. Come to find out Akita blood platelets can explode in storage causing hi readings. The Vet's are so busy that even if you can get in you don't get anywhere. Seizures are going on two hours.. The FDA considers products in the isoxazoline class to be safe and effective for dogs and cats but is providing this information so that pet owners and veterinarians can take it into consideration when choosing flea and tick products for their pets. Please do NOT use it!! 2-6 days in vomiting here and there. I was giving my 70 lb golden doodle Trifexus, for nearly 2 years until suddenly he refused to eat it. I feel like it was a massive overdose. This medicine needs to be stopped. Please anyone let me know if there is a class action law suit or where we can start one? Then suddenly dog has diarrhea and it lasted for several days. Yea so what about the 10 percent? If anyone has suggestions or knows how else I can help my little guy please let me know. Very small sample - many deformities, stillborn. The following list includes the known side effects of Simparica. Training your dog to follow basic commands builds a positive relationship with her and helps ensure her safety. Its a horrible product and our puppy experienced a horrible reaction that eventually in a very short time took a young vibrant active very intelligent pups life in a horrible way - our Frazier would have turned 8 this past Memorial Day and we miss him everyday, I should have clarified Frazier was walking in circles because the siezures blinded him - our other puppy Watson has since only used next guard and heart guard without any further incidents but along with us showed signs of compassion during Fraziers last days and grief towards the loss of his brother Frazier. She was shaking like she was freezing. Yesterday one baby threw up four times within one hour of taking her chewable. While veterinarians often prescribe medications for off-label uses, your veterinarian will determine whether Simparica is right for your pet. That evening after giving it to him he has puked various times. A month later, he was at doggie daycare and we picked him up and he was panting frantically. The vet and company are in consultation. It's only available with a prescription from your veterinarian, so you cannot get it over-the-counter. He had an MRI and it came out good. Maybe dont have a dog. I wanted to investigate a bit before dosing him. I hope it is taken off the market and request that anyone on this thread with a pet who has suffered due to this drug goes to this link from the FDA to officially report their pet's adverse side effects: https://www.fda.gov/animal-veterinary/report-problem/how-report-animal-drug-side-effects-and-product-problems. Simparica, Nexgard, Bravecto and Credelio are part of a group called Isoxazoline drugs. She had some good days and we were hopeful but ultimately, she steadily declined. This will kill fleas and ticks. I not any kind of a medical doctor nor am I a vet however I do often research many topics on health related matters both canine and human for decades and then use my common sense to draw logical conclusions or make reasonable guesses. She's a Brittany (Spaniel). Sadly and heartbroken I report a follow up that our healthy very active 7 yr old blue tick beagle did not make it - Frazier took his last breath on February 25 2021 - he only declined the seizures continued he was fatigued all the time started losing control of his bladder - and losing his balance and walking in circles we kept hoping that once the poison was out of him he would improve but sadly he only declined I spent many nites sitting with him because the seizures were getting so bad - we tried everything but our vet tried with us but on Feb 25th our vet said that Frazier had enough and he would not recover - I did contact the company as my vet recommended and the worst customer service reps especially in this situation all they wanted was his vet records in a very matter of fact tone as I kindly replied in southern style - kiss my biscuits!! I sure hope he makes it! I looked up side effects for this drug and was horrified to find that the flea med can cause tremors seizures and worse. It comes in a pack of six or 12, but veterinarians typically sell individual doses for growing puppies. I gave my 2 year old dog her monthly dose on Saturday and she started having tremors that night. Revolution has been around decades with less incidents of animal reactions. So, I gave it to him. Daily Paws is part of the Meredith National Digital Network. I dont want to have to put my dog down but hes suffering. The costs associated with these two products are roughly the same. I am so angry. The diarrhea and vomiting went away after a few days but the cough has lingered for over a month now even with treatment. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Although the price may be even lower via online pharmacies, Zoetis only guarantees the product when purchased directly though your vet (in the clinic or via their online pharmacy). She said to watch for drainage. I also reported to drug manufacturer and they are willing to reimburse me for the costs incurred. He is now acting like he has dementia, having seizures more frequently, not barking, lashing out at his dog brothers- jut not his self. Has anyone else experienced this? I have always been apprehensive about putting my dog on Heartworm / Flea Tick medication because of horror stories, but I thought he's 5 and it will be from the vet and it seems like the responsible thing to do. We did get a little symptom improvement from prednisone if they are having other neurological issues. She is more worried about excessive thirst, lip smacking and her kidneys. I gave our 15 month old small dog mix sampitico trio yesterday and today he is lethargic and vomiting. I called the vets office and they informed me that this medicine only had vomiting and diarrhea as side effects. He has been resting most of the day so far, thankfully no seizures.. but I promise I will not be giving him the other 2 doses I got from the vet after reading all of the experiences everyone else has had with their animals. But he had a terrifying seizure when I was out walking him on December 26, 2020 with no previous known history (he is rescue I've had since he was 2). Gave Simparica yesterday and am suspect. Mine passed within 24 hours of the first dose. Yes Id like to know that answer myself. She has been on it for 6 months. We are currently going through this with our nine year old dachshund. Next day she seemed different, standing slightly strangely. I don't want another animal harmed by this stuff, one animal is one to many. Very dissapointed with my vet for not informing me of the risk this has on my dog. I would not recommend giving Simparica to your pets!!!!! If these symptoms appear on your pet, do not worry, it is normal after taking a dose of Simparica. Neurologist doesnt seem to really know if the effects are long term or not. I say yes! If you miss a dose of Simparica Trio, give it immediately and resume monthly dosing. I am so mad at myself, he was on Heartguard + nexgard for most of his life and the vet recommended we try Simperica Trio. 24 hours after, we noticed diarrhea. I need to tell my vet to switch! And then when we finally stop for the evening - she crashes. Simparica only offers chewables. Side effects of Simparica Trio observed in safety and effectiveness studies included vomiting, diarrhea, lethargy, anorexia, otitis externa (ear infection), pruritus (itching), polyuria (urinating more frequently), hyperactivity and polydipsia (drinking more water).. Is Simparica Trio killing dogs? corgi lying in grass next to woman's feet. He was vomiting, had diarrhea, urinating constantly and the very scary part were the uncontrollable tremors. He was diagnosed with "Sundowners" . The personality change is what has me most concerned too. Side-Effects Of Simparica Trio Tablets There are some mild side effects like Vomiting Diarrhea Loss of appetite Dog owners should be aware that these tablets are not suitable for all dogs. I thought maybe he got into something. How is ur puppy? Also what are you looking at giving your dog as a seizure medication?? I have always used topical tx. His motor skills have been affected and hes been losing weight even though he eats heartily. Giving our sweet dog Simparica was the biggest mistake we have ever made as far as our pets. Hopefully there are many other dogs that are unaffected, and just aren't written about here. This was the only thing we changed, I am convinced this is what did it to her. Another call to vet asking for an appt - seems like an an emergency now? Did the tremors ever stop? And it looks like the liver and/or the kidney will not take it too. It may or may not be the cause but I need to do everything in my power to bring my dog back to health. How can you give a dog a pesticide to ingest. She has been taking Trifexis for years with no problem. I sure hope we don't have ongoing problems. OMG - I am so mad at myself for not doing more research. for flea and ticks? 12/18/21.. he did experience some diarrhea. Before sharing sensitive information, make sure you're on a federal government site. All Rights Reserved. The only thought in my head was to get home and give it to my puppy who has had few fleas, but many itching problems. This drug has caused our dog to loose his footing and not eat. Called his vet and they gave no information. Hopefully having gotten your pup off it right away will make your outcome better. Thankfully there have been no other side effects. He has horrible water like stools. Again he has diarrhea and this month he seems agitated or nervous. This is worth the cost to buy a six-pack of protection. This was days ago when I could still get food into him and the result. Millions of dogs take flea and heartworm meds without side effects but that's not to say it doesn't happen or that an alternative would be safer. org to have this poison recalled. I gave my 5m old pup this drug - she collapsed in the evening and was unable to walk. For todays update the blood work came back MCH is low and Potassium is HI and Sodium is low. Poor dog prob thinks HE did something wrong. Vets at Petsmart should know better; changing vets. Just gave this to my 2 year old 77 lb boxer 5 hours ago and I'm SCARED! Maybe? He is very whinny and is drinking a lot of water. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. I will never use this product again!!!!! Hi there, So sorry to hear about your dog. I'm just so angry that the vet prescribed this and I am mad at myself for not researching it. Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . Today is Friday. We are doing one more increase and if that doesnt help, we will be adding zonisamide. So sad as he was once a happy healthy dog with no prior health issues. After second pill, weve notice he has been a bit down for a couple days. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! She's not drinking water or eating all she wants to do is sleep. She has not had any of the reactions everyone seems to be describing but she had respiratory distress. This medicine is making her shaky/tremor, anxious, and she is panting a ton. Ticks are horrible here in Maine. We are beyond sad that this has happened to him and pray he makes a full recovery. Simparica and Simparica Trio are available by prescription only. Vet gave her a shot which stopped it. I gave him this medication last Thursday. Sarolaner is effective against the following tick species: Moxidectin is an antiparasitic drug in the macrocyclic lactone class. A couple of weeks later she had lost weight from not eating. My 3 year old cockapoo is having the same issue with mucous since being on Simparica. My sincere sympathies to those with horrendous seizure side effects. Read the package insert and it does list tremors and seizures as a side effect. The reaction lasted less than 12 hours. I sadly started my beautiful dog on Simparica Trio on May 1, 2021. Hope all is well. My 3 other poodles unaffected. This past October he just wasn't the same. My dog is having the same issues. So we went home with her on steroids and more antibiotics and denamrin for liver. I would notice he gets super tired walking and would go limp in my arms. Manufactured by Zoetis, Simparica Trio contains three drugs: sarolaner, moxidectin, and pyrantel pamoate. Eyes roll back. she has shaking off and on . We have never had issues with him peeing in the house - EVER, and he peed in my office. He just isnt himself. Simparica TRIO requires a prescription from your veterinarian. She had some itching and a bit lethargic but is eating very well. These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. Really? If most side effects are mild, ( vomiting 12 hours later could be due to other things the dog has eaten within those 12 hours), I am ok with that. You don't think I'm going to continue with this poison. I just almost had a similar incident with my 16wk cavapoo. I would, still boil chicken, carrots, potatoes for his meals. Our baby isnt the same at all since his one and only dose of Simparica. She seems so much happier in herself but until she comes off the keppra completely I wont know if it's a reversible problem. I started crying carrying his body to my husband . We did not make the connection until today. Our 9 month 5lb Morkie was prescribed this garbage and we noticed the shakes, his lower lip quivering, and he looks around as if an invisible fly is flying around his head. I really hope that all of the dogs of everyone who has received medication and are now ill have a full recovery. I do believe it caused her blindness. Also - do NOT use Bravecto for females you intend to breed. After about 35 days he was back to normal. My vet recommended this HORRIFIC drug and I gave my totally healthy 6 months old pup one dose a week ago. This sounds so scary. Animal Drug Safety Communication: FDA Alerts Pet Owners and Veterinarians About Potential for Neurologic Adverse Events Associated with Certain Flea and Tick Products, How to Report Problems with Flea and Tick Products, An official website of the United States government, : Simparica Trio contains three active ingredients . I gave my 1 year old collie cross Simparica flea and tick medication. She text me asking if she ever had seizures before. When he lays in the sun you can see the bumps under his skin. Once she is completely healed I am putting her back on those. I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. First it was a fake guess of Lyme (she's from Texas where Lyme is not) disease diagnosis and $1200 wasted. Currently we are monitoring him closely-hes never been sick. Im done with this drug! It is the most convenient flea and tick protection product on the market. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Does anyone know of anything we can give her to help get this out of her system? Both my dogs have had runny eyes and were eating grass all summer. They were good to deal with. He said it would take care of ticks and Trifexis doesn't. Its been 3 months and she continues to have them. I'm hoping the tremors will soon diminish, since she is in great shape otherwise. After seeing his condition worsen, that night we took him to an after hours urgent care. And how long for this sheet to get out of the dogs system??? Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. Even when we specifically mentioned the new information he still had nothing but the original tests to go off of. Just wondering? It all depends, sadly. Use topical or a collar if you are concerned. I feel the manufacturer should pay my test bills and meds .. my doc talked me into this regimine of meds and my previous dog did well on sorresto color and heart word med .. any clue on who I contact ? He first started with seizures and losing weight in June after giving him Simparica. I realized he had no control over his body . Took him back to the vet. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. My Jack Russell Terrier has taken Simparica Trio for several months. This is terrible. Saving money sounds great, right? My dog is on a "health care plan" with my vet. It really helped us to put this diarrhea condition in perspective. Side effects of Simparica Let us now look at possible side effects when administering Simparica. https://photos.app.goo.gl/GbP8UmDNBAxJ1m4g8 I feel like we are just waiting for him to pass now. No running or jumping, Continuously wandering around the fence line of the back yard. Update June 7th. And how do we get the word out to everyone? I hope this product is no longer sold anywhere. Each tablet is formulated to provide minimum dosages of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 g/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt). This is so awful. I have an 8 year old Labrador. I gave my dog simparica at 10:15am. He is still not himself, walks very slowly and is definitely not feeling his best. I went and picked her up today and all she does is lay around and drink water, turns her nose up at anything food related. He also had a seizure that lasted for about 2 minutes in the middle of the night about 2 months ago and it was the most horrifying thing to watch and feel so helpless. No more of this med! From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. Simparica Trio is not effective against adult heartworms. Update on my Labradoodle who started seizures just a few hours after receiving first dose of Simparica on T-Day 2020 it is March 2021 and my Vet put my dog on Phenobarbital for anti-seizure med. I let him back in the bedroom yesterday all went well, then this morning I woke to him peeing in the floor again. Lost his appetite & was low on energy all day yesterday, slept most of the day - which is very unusual for him. Gave our pup of 10 years the Simparica Trio as suggested by our vet 1 week ago instead of the Simparica and Interceptor he had been on for 7 years with no problems. Use with caution in dogs with a history of seizures. I disagree. It is Easter Sunday and he still has diarrhea and drinking a crazy amount of water. Seems like it was directly related to the medication. Next she developed severe tremors. If there are enough reports they may have to pull it off the market until further safety tests can be done. Simparica is good at killing contagious parasites that cause mange and scabies. This Tuesday the 17th I had given my dog simparica trio for 27lbs dose. What are the side effects of Simparica trio for dogs? My dog has had 3 seizures in the past from wearing a flea collar. He is otherwise normal and healthy. He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. I just gave Bentlee my Akita Simparica Trio on the 9th. My family saw it , I did not . Today June 1,2022 she is still having neurological problems. my vet recommended this for both my yorkies. I will never give another dose to him! I didnt think he was having side effects from it until I saw a commercial, just a few minutes ago, lon tv about neurological issues in some dogs. My nearly 14 year old Havanese Kokomo has taken a sharp decline in the last 8 month and I was blaming it on old age when I think I may have been poisoning him. He woke up and seemed much brighter. I am also going to contact the vet who gave it to me and tell him all this stuff. And im so mad that my vet didn't inform me of the side effects and im so mad I didn't research it myself. Started giving my dogs Simparica Trio 5 months ago didn't put together the changes in the one dogs personality until today within a couple of weeks she would all of a sudden go from a loving dog to attacking the other dog it is getting worse. I am so worried after reading these comments. I am continuing to recover at home and have to use an oxygen tank. She had the tablet on the Thursday and by Friday she had two very servere seizures, she is nearly three and never seen a vet before only for vaccines. I lost my previous bichon poo to seizures 2 years ago and I dont want to go through that type of pain and lost again! She won't drink E walk or anything The doctor seemed to push this drug on me because the kombi guard was on back order. So far, the cost of diagnostic tests are about $700. Bentlee trusts me an I let him down on this one. 4.3 4.3 out of 5 stars (34,534) $39.98 $ 39. My dogs have been throwing up since then and I could not for the life of me figure out why. My Pomeranian is on a steady decline after taking 1 dose. Two months no flare up no more scabs and loosing hair. Meaning he is suppose to get it today. Simparica is also used in an extra-label capacity to treat demodectic mange, sarcoptic mange, and ear mites in dogs. Are their enough people to file a class action suit? like what??? 13 March he is also very lethargic and sitll not eating (even his favorite treats). First time for this adverse reaction. After weekly re-infestations, SIMPARICA TRIO reduced the number of live fleas by 97.8% within 12 hours of infestation for 28 days. I'm besides myself. Thanks Michelle! I am so mad at myself and so upset that I am the one that has made him sick. Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. Final Thoughts on Trifexis vs Simparica. In a weak moment last week she prescribed Simparica for a flea problem my 5 year old Springer was having. He had no medical problems before this, and I took him to the vet every year he ended up dying two weeks later , I took him to the vet first they told me he wasnt gonna make it to leave him there and I told him no if he isnt gonna make it, hes going to pass away in my arms at home with me and his family why took him to a different vet not the same one I confronted the woman that gave me that medicine. The vet does not feel it is due to Simparica but i think it could be. Didnt notice anything with first dose. Seriously I have had the worse luck. I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! My veterinarian did not warn me of these and now my precious boxer is gone!!!!! I wish every one the best. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Im switching back to the old stuff. One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. Two weeks after first simparica dose.parasites gone. Now do you get the connection? He has trouble raising his leg to urinate. I hope it has no permanent impact on him. Could this be caused by the med? The excerpts below from the manufacturers' Prescribing . Yep days ago started vomiting and having seizures. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. If I still lived in the city, I would probably use the garlic because the previous GS never had any issues and lived a long time. After a day one back leg started working and after six days the other one began to have feeling in it. Not grass grazing either. I hope and pray for no long term affects. 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